Hereditary kidney diseases in children and adults (MARHEA)

French national reference center for hereditary kidney diseases in children and adults (MARHEA)

logo-MARHEA

drapeau françaisThe constituent site of the reference center for hereditary kidney diseases in children and adults (MARHEA) at the Georges-Pompidou european hospital (HEGP) focuses on the management of hereditary tubulopathies, arterial hypertension of monogenic origin and aldosterone-associated pathologies of hereditary character.

It integrates the following activities :

  • Genetics of hereditary tubulopathies : this activity, carried out within the genetics department of the HEGP directed by professor Xavier Jeunemaître, includes diagnosis in molecular genetics (Dr Rosa Vargas-Poussou, Dr Maria Cristina Zennaro and Dr Marguerite Hureaux) and genetic consultations (Pr Xavier Jeunemaitre, Dr Rosa Vargas-Poussou and Dr Maria Cristina Zennaro).
  • Functional exploration of adult patients with hereditary or acquired renal tubulopathies : activity carried out in the day hospital of the physiology-functional explorations department (Pr Pascal Houillier).
  • Clinical consultation for rare diseases : the care and follow-up of adult patients with renal tubulopathies is ensured by the consultations of Pr Pascal Houillier, the physicians of the physiology department and Dr Anne Blanchard.

This reference center is affiliated with the ORKID rare diseases healthcare network and the ERKNet European reference network (ERN).
.                             logo-orkid                      Logo-ERKNet

Medical team

Pascal Houillier photo CAP HEGP

Head of the reference center
Pr Pascal Houillier
MD, PhD

Photo Hureaux MARHEA HEGP

Dr Marguerite Hureaux
MD, PhD

Contact us

  • Genetics phone: +33 1 56 09 52 29
  • Consultation Dr Blanchard : +33 1 56 09 30 69
  • Physiology and functional explorations department: +33 1 56 09 56 25 or +33 1 56 09 39 69

> Send an email

In case of emergency

appel urgence Marhea English HEGP

Our constituent center provides the following missions :

  • Recourse mission : our center ensures the diagnosis and follow-up of patients with hereditary renal tubulopathies with the following activities: consultation on renal and metabolic diseases; genetic consultation; day hospital for renal and metabolic functional explorations.
  • Local and national expertise mission : our centre has nationally recognised expertise in the exploration of renal tubular functions for adult patients, the management of renal tubulopathies, both hereditary and acquired, in adults and the molecular genetic diagnosis of most of the genes for hereditary renal tubulopathies.  This last activity has allowed us to gather and analyse clinical and biological information from patient files from all over the country and to better understand the natural history and the different clinical presentations of hereditary tubulopathies. Difficult cases are discussed with the prescribing doctors and during our consultation meetings to orientate complementary examinations and relevant genetic analyses.
  • Teaching and training mission : all the center’s doctors are experts in one or more diseases and regularly give lectures and training sessions in France and/or abroad in the field of hereditary renal tubulopathies.
  • Research mission : we work in close collaboration with the clinical investigation centre (CIC) of the HEGP and other centers, which has enabled us to develop multicenter clinical trials. Three of the doctors involved in our activity are also INSERM team leaders: Pr Xavier Jeunemaitre in charge of team 3 (genetics of rare arterial diseases) at PARCC (INSERM_U970) and Dr Maria-Christina Zennaro in charge of team 14 (genetic mechanisms of aldosterone related disorders) at PARCC (INSERM_U970), which allows us to study in depth the pathophysiological mechanisms of these rare pathologies. Pr Pascal Houillier, co-leader of the « metabolism and renal physiology » team at the Cordeliers research center (INSERM UMR_S1138).
  • Pr Pascal Houillier – Nephrologist, head of the reference center
  • Dr Rosa Vargas-Poussou – Paediatric nephrologist and biologist
  • Dr Maria Christina Zennaro – Endocrinologist and biologist
  • Dr Anne Blanchard – Nephrologist
  • Dr Caroline Prot-Bertoye – Nephrologist
  • Dr Marine Livrozet, Nephrologist
  • Dr Marguerite Hureaux – Biologist
  • Eléonore de Latour – Secretary
  • Laura Poli – Dietitian and nutritionist

RESEARCH

  • Dose-Dependent Effect of Thiazide in Dent’s Disease Hypercalciuria (DESY) – PHRC NCT00638482 – CIC1418 – Dr Anne Blanchard (Finalized)
  • Input of the Use of Indometacin in Gitelman Syndrome as Compared to Potassium Sparing Diuretics (GITAB) – PHRCN – NCT01146197 – CIC1418 – Dr Anne Blanchard (Finalized)
  • Clinical Significance of Heterozygosity for Mutations of the SLC12A3 Gene Coding for the Thiazide Sensitive Na-Cl Cotransporter (HEPHYGI)– PHRCN – NCT02035046 – Génétique – Dr Vargas-Poussou (Finalized)
  • Randomized cross-over trial comparing recombinant human PTH (1-34) with alfacalcidol-hydrochlorothiazide in the treatment of autosomal dominant hypocalcemia (ACTICAS) – PHRCN – NCT02824718 – CIC1418 – Dr Anne Blanchard (Finalized)
  • Tight junctions: from structure to treatment – T-JUST: T-JUST (ANR) – UMRS1138 – Pr Houillier (In progress)
  • Programme Equipes FRM 2018: Genetic mechanisms of aldosterone related disorders – towards integrative precision medicine – Inserm U970 PARCC, équipe 12 MC Zennaro  (In progress)
  • ANR Collaborative research projects – International, Call for generic projects 2018 ANR-FNS : GenAdEx, Genetic and molecular contributors to adrenocortical hormone excess – Inserm U970 PARCC, équipe 12 MC Zennaro (In progress)
  • Horizon 2020, H2020-PHC-2014-two-stage: ENSAT-HT, Omics-based strategies for improved diagnosis and treatment of endocrine hypertension -Inserm U970 PARCC, équipe 12 MC Zennaro (In progress)
  • H2020-MSCA-ITN-2020: MINDSHIFT “Mechanistic Integration of vascular aND endocrine pathways for Subtyping Hypertension: an Innovative network approach for Future generation research Training” – Inserm U970 PARCC, équipe 12 MC Zennaro (In progress)

2021

– Defects in KCNJ16 Cause a Novel Tubulopathy with Hypokalemia, Salt Wasting, Disturbed Acid-Base Homeostasis, and Sensorineural Deafness.
Schlingmann KP, Renigunta A, Hoorn EJ, Forst AL, Renigunta V, Atanasov V, Mahendran S, Barakat TS, Gillion V, Godefroid N, Brooks AS, Lugtenberg D, Lake J, Debaix H, Rudin C, Knebelmann B, Tellier S, Rousset-Rouvière C, Viering D, de Baaij JHF, Weber S, Palygin O, Staruschenko A, Kleta R, Houillier P, Bockenhauer D, Devuyst O, Vargas-Poussou R, Warth R, Zdebik AA, Konrad M.
J Am Soc Nephrol. 2021 Jun 1;32(6):1498-1512. doi: 10.1681/ASN.2020111587. Epub 2021 Apr 2. PMID: 33811157

Somatic mutations in adrenals from patients with primary aldosteronism not cured after adrenalectomy suggest common pathogenic mechanisms between unilateral and bilateral disease.
Hacini I, De Sousa K, Boulkroun S, Meatchi T, Amar L, Zennaro MC, Fernandes-Rosa FL.
Eur J Endocrinol. 2021 Jul 1:EJE-21-0338.R2. doi: 10.1530/EJE-21-0338. Online ahead of print. PMID: 34232123

Differential localization patterns of Claudin 10, 16 and 19 in human, mouse, and rat renal tubular epithelia.
Prot-Bertoye C, Griveau C, Skjødt K, Cheval L, Brideau G, Lievre L, Ferriere E, Arbaretaz F, Garbin K, Zamani R, Marcussen N, Figueres L, Breiderhoff T, Müller D, Bruneval P, Houillier P, Dimke H.
Am J Physiol Renal Physiol. 2021;185:405-412. doi: 10.1152/ajprenal.00579.2020. PMID: 34151590

New insights into the role of endoplasmic reticulum-associated degradation in Bartter Syndrome Type 1.
Shaukat I, Bakhos-Douaihy D, Zhu Y, Seaayfan E, Demaretz S, Frachon N, Weber S, Kömhoff M, Vargas-Poussou R, Laghmani K.
Hum Mutat. 2021 Aug;42(8):947-968. doi: 10.1002/humu.24217. Epub 2021 May 31. PMID: 33973684

Diversity of functional alterations of the ClC-5 exchanger in the region of the proton glutamate in patients with Dent disease 1.
Sakhi I, Bignon Y, Frachon N, Hureaux M, Arévalo B, González W, Vargas-Poussou R, Lourdel S. Hum Mutat. 2021 May;42(5):537-550. doi: 10.1002/humu.24184. Epub 2021 Mar 1. PMID: 33600050

[Cystinuria].
Caroline Prot-Bertoye, Michel Daudon, Isabelle Tostivint, Marie-Paule Dousseaux, Jérôme Defazio, Olivier Traxer, Bertrand Knebelmann, Marie Courbebaisse
Nephrol Ther, 2021 Apr, PMID: 33910689 DOI: 10.1016/j.nephro.2020.03.001

Biochemical assessment of phosphate homeostasis.
Pascal Houillier, Jean-Pierre Salles
Arch Pediatr, 2021 Oct, PMID: 34598836 DOI: 10.1016/j.arcped.2021.09.001

The variety of genetic defects explains the phenotypic heterogeneity of Familial Hyperkalemic Hypertension.
Marguerite Hureaux, Stephani Mazurkiewicz, Valerie Boccio, Rosa Vargas-Poussou, Xavier Jeunemaitre
Kidney Int Rep, 2021 Aug 2, PMID: 34622103 PMCID: PMC8484123 DOI: 10.1016/j.ekir.2021.07.025

When a maternal heterozygous mutation of the CYP24A1 gene leads to infantile hypercalcemia through a maternal uniparental disomy of chromosome 20.
Marguerite Hureaux, Sandra Chantot-Bastaraud, Kévin Cassinari, Edouard Martinez Casado, Ariane Cuny, Thierry Frébourg, Rosa Vargas-Poussou, Anne-Claire Bréhin
Mol Cytogenet, 2021 May 5, PMID: 33952337 PMCID: PMC8101107 DOI: 10.1186/s13039-021-00543-4

Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism.
Scott M MacKenzie, Hannah Saunders, Josie C van Kralingen, Stacy Robertson, Alexandra Riddell, Maria-Christina Zennaro, Eleanor Davies
Cancers (Basel), 2021 Oct 22, PMID: 34771478 PMCID: PMC8582381 DOI: 10.3390/cancers13215312

Diagnosis and management of Bartter syndrome: executive summary of the consensus and recommendations from the European Rare Kidney Disease Reference Network Working Group for Tubular Disorders.
Martin Konrad, Tom Nijenhuis, Gema Ariceta, Aurelia Bertholet-Thomas, Lorenzo A Calo, Giovambattista Capasso, Francesco Emma, Karl P Schlingmann, Mandeep Singh, Francesco Trepiccione, Stephen B Walsh, Kirsty Whitton, Rosa Vargas-Poussou, Detlef Bockenhauer
Kidney Int, 2021 Feb, PMID: 33509356 DOI: 10.1016/j.kint.2020.10.035

Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse.
Mengyao Yu, Sergiy Kyryachenko, Stephanie Debette, Philippe Amouyel, Jean-Jacques Schott, Thierry Le Tourneau, Christian Dina, Russell A Norris, Albert A Hagège, Xavier Jeunemaitre, Nabila Bouatia-Naji
Circ Genom Precis Med, 2021 Oct, PMID: 34461747 PMCID: PMC8530910 DOI: 10.1161/CIRCGEN.120.003148

Recurrent Nephrolithiasis in a Patient With Hypercalcemia and Normal to Mildly Elevated Parathyroid Hormone.
Alexander Ritter, Rosa Vargas-Poussou, Nilufar Mohebbi, Harald Seeger
Am J Kidney Dis, 2021 Jun, PMID: 34024353 DOI: 10.1053/j.ajkd.2020.09.022

Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause.
Junhua Zhou, Elena A B Azizan, Claudia P Cabrera, Fabio L Fernandes-Rosa, Sheerazed Boulkroun, Giulia Argentesi, Emily Cottrell, Laurence Amar, Xilin Wu, Sam O’Toole, Emily Goodchild et al.
Nat Genet, 2021 Sep, PMID: 34385710 PMCID: PMC9082578 DOI: 10.1038/s41588-021-00906-y

2020

Medullary and cortical thick ascending limb: similarities and differences.
Lise Bankir, Lucile Figueres, Caroline Prot-Bertoye, Nadine Bouby, Gilles Crambert, J Howard Pratt, Pascal Houillier
Am J Physiol Renal Physiol, 2020 Feb 1, PMID: 31841389 DOI: 10.1152/ajprenal.00261.2019

Old and new genes in primary aldosteronism.
Sheerazed Boulkroun, Fabio Luiz Fernandes-Rosa, Maria-Christina Zennaro
Best Pract Res Clin Endocrinol Metab, 2020 Mar, PMID: 32007424 DOI: 10.1016/j.beem.2020.101375

Claudins in Renal Physiology and Pathology.
Caroline Prot-Bertoye, Pascal Houillier
Genes (Basel), 2020 Mar 10, PMID: 32164158 PMCID: PMC7140793 DOI: 10.3390/genes11030290

Genetic and Genomic Mechanisms of Primary Aldosteronism.
Fabio L Fernandes-Rosa, Sheerazed Boulkroun, Maria-Christina Zennaro
Trends Mol Med, 2020 Sep, PMID: 32563556 DOI: 10.1016/j.molmed.2020.05.005

[Bartter-Gitelman syndromes].
Anne Blanchard, Pierre-Yves Courand, Marine Livrozet, Rosa Vargas-Poussou
Nephrol Ther, 2020 Jul, PMID: 32622651 DOI: 10.1016/j.nephro.2020.06.001

Pathogenesis and treatment of primary aldosteronism.
Maria-Christina Zennaro, Sheerazed Boulkroun, Fabio L Fernandes-Rosa
Nat Rev Endocrinol, 2020 Oct, PMID: 32724183 DOI: 10.1038/s41574-020-0382-4

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Hélène Louis-Dit-Picard, Ilektra Kouranti, Chloé Rafael, Irmine Loisel-Ferreira, Maria Chavez-Canales, Waed Abdel-Khalek, Eduardo R. Argaiz, Stéphanie Baron, Sarah Vacle, Tiffany Migeon, Richard Coleman Marcio Do Cruzeiro, Marguerite Hureaux, Nirubiah Thurairajasingam, Stéphane Decramer, Xavier Girerd, Kevin O’Shaugnessy, Paolo Mulatero, Gwenaëlle Roussey, Ivan Tack, Robert Unwin, Rosa Vargas-Poussou, Olivier Staub, Richard Grimm, Paul A. Welling, Gerardo Gamba, Eric Clauser, Juliette Hadchouel and Xavier Jeunemaitre
J Clin Invest, 2020 Dec 1, PMID: 32790646 PMCID: PMC7685730 DOI: 10.1172/JCI94171

QT Interval in Adult with Chronic Hypokalemia due to Gitelman Syndrome: Not so Frequently Prolonged.
Pierre-Yves Courand, Pedro Marques, Rosa Vargas-Poussou, Michel Azizi, Anne Blanchard, GITAB study investigators
Clin J Am Soc Nephrol, 2020 Nov 6, PMID: 32792351 PMCID: PMC7646245 DOI: 10.2215/CJN.07540520

Persistently high urine glucose levels caused by familial renal glycosuria.
D Djeddi, A Cauliez, A Oulebsir, M Hureaux, A Vanrenterghem, R Vargas-Poussou
Arch Pediatr, 2020 Oct, PMID: 32807621 DOI: 10.1016/j.arcped.2020.07.002

Renin-aldosterone system evaluation over four decades in an extended family with autosomal dominant pseudohypoaldosteronism due to a deletion in the NR3C2 gene.
Aaron Hanukoglu, Rosa Vargas-Poussou, Zohar Landau, Keren Yosovich, Marguerite Hureaux, Maria-Christina Zennaro
J Steroid Biochem Mol Biol, 2020 Nov, PMID: 33017655 DOI: 10.1016/j.jsbmb.2020.105755

Investigation of Vestibular Function in Adult Patients with Gitelman Syndrome: Results of an Observational Study.
Mihaela Alexandru, Marie Courbebaisse, Christine Le Pajolec, Adeline Ménage, Jean-François Papon, Rosa Vargas-Poussou, Jérôme Nevoux, Anne Blanchard
J Clin Med, 2020 Nov 23, PMID: 33238651 PMCID: PMC7700665 DOI: 10.3390/jcm9113790

Defective bicarbonate reabsorption in Kir4.2 potassium channel deficient mice impairs acid-base balance and ammonia excretion.
Yohan Bignon, Laurent Pinelli, Nadia Frachon, Olivier Lahuna, Lucile Figueres, Pascal Houillier, Stéphane Lourdel, Jacques Teulon, Marc Paulais
Kidney Int, 2020 Feb, PMID: 31870500 DOI: 10.1016/j.kint.2019.09.028

Red Blood Cell AE1/Band 3 Transports in Dominant Distal Renal Tubular Acidosis Patients.
Jean-Philippe Bertocchio, Sandrine Genetet, Lydie Da Costa, Stephen B Walsh, Bertrand Knebelmann, Julie Galimand, Lucie Bessenay, Corinne Guitton, Renaud De Lafaille, Rosa Vargas-Poussou, Dominique Eladari, Isabelle Mouro-Chanteloup
Kidney Int Rep, 2020 Jan 13, PMID: 32154456 PMCID: PMC7056926 DOI: 10.1016/j.ekir.2019.12.020

Clinical characteristics of familial hypocalciuric hypercalcaemia type 1: A multicentre study of 77 adult patients.
Céline Mouly, Rosa Vargas-Poussou, Anne Lienhardt, Caroline Silve, Marguerite Hureaux, Corinne Magdelaine, Alexandre Buffet, Solange Grunenwald, Jean-Marc Kuhn, Thierry Brue, Yves Reznik, Antoine Tabarin, Dominique Martin-Coignard, Jean-Philippe Haymann , Ivan Tack, Antoine Bennet, Philippe Caron, Agnès Linglart, Delphine Vezzosi, Reference Centre for Rare Diseases of Calcium, Phosphate Metabolism
Clin Endocrinol (Oxf), 2020 Sep, PMID: 32347971 DOI: 10.1111/cen.14211

Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension.
Paolo Mulater, Silvia Monticone, Jaap Deinum, Laurence Amar, Aleksander Prejbisz, Maria-Christina Zennaro, Felix Beuschlein, Gian Paolo Rossi, Tetsuo Nishikawa, Alberto Morganti, Teresa Maria Seccia, Yen-Hung Lin, Francesco Fallo, Jiri Widimsky
J Hypertens, 2020 Oct, PMID: 32890264 DOI: 10.1097/HJH.0000000000002510

Aldosterone-Related Myocardial Extracellular Matrix Expansion in Hypertension in Humans: A Proof-of-Concept Study by Cardiac Magnetic Resonance.
Alban Redheuil, Anne Blanchard, Helena Pereira, Zainab Raissouni, Aurelien Lorthioir, Gilles Soulat, Rosa Vargas-Poussou, Laurence Amar, Jean-Louis Paul, Dominique Helley, Michel Azizi, Nadjia Kachenoura, Elie Mousseaux
JACC Cardiovasc Imaging, 2020 Oct, PMID: 32950448 DOI: 10.1016/j.jcmg.2020.06.026

A Rare Cause of Chronic Hypokalemia with Metabolic Alkalosis: Case Report and Differential Diagnosis.
Cristina Bertulli, Marguerite Hureaux, Chiara De Mutiis, Andrea Pasini, Detlef Bockenhauer, Rosa Vargas-Poussou, Claudio La Scola
Children (Basel), 2020 Nov 5, PMID: 33167351 PMCID: PMC7694404 DOI: 10.3390/children7110212

2019

Resistance to Insulin in Patients with Gitelman Syndrome and a Subtle Intermediate Phenotype in Heterozygous Carriers: A Cross-Sectional Study.
Blanchard, A ; Vallet, M ; Dubourg, L ; Hureaux, M ; Allard, J ; Haymann, JP & al
J Am Soc Nephrol, 2019 Aug, PMID: 31285285 PMCID: PMC6683723 DOI: 10.1681/ASN.2019010031

High-throughput sequencing contributes to the diagnosis of tubulopathies and familial hypercalcemia hypocalciuria in adults.
Hureaux, M ; Ashton, E ; Dahan, K ; Houillier, P ; Blanchard, A ; Cormier, C & al
Kidney Int, 2019 Dec, PMID: 31672324 DOI: 10.1016/j.kint.2019.08.027

Severe Arterial Hypertension from Cullin 3 Mutations Is Caused by Both Renal and Vascular Effects.
Abdel Khalek, W ; Rafael, C ; Loisel-Ferreira, I ; Kouranti, I ; Clauser, E ; Hadchouel, J & al
J Am Soc Nephrol, 2019 May, PMID: 30967423 PMCID: PMC6493989 DOI: 10.1681/ASN.2017121307

Molecular mechanisms in primary aldosteronism
De Sousa, K ; Abdellatif, AB ; El Zein, RM ; Zennaro, MC
J Mol Endocrinol, 2019 Sep 1, PMID: 31397984 DOI: 10.1530/JOE-19-0193

Treatment and long-term outcome in primary distal renal tubular acidosis.
Lopez-Garcia, SC ; Emma, F ; Walsh, SB ; Fila, M ; Hooman, N ; Zaniew, M & al
Nephrol Dial Transplant, 2019 Jun 1, PMID: 30773598 DOI: 10.1093/ndt/gfy409

The Case Severe hypertension and hyperkalemia in a kidney transplant recipient.
Dupont, V ; Colosio, C ; Hureaux, M ; Mokri, L ; Schvartz, B ; Vuiblet, V & al
Kidney Int, 2019 Aug, PMID: 31331484 DOI: 10.1016/j.kint.2019.01.022

Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism.
Göppner, C ; Orozco, IJ ; Hoegg-Beiler, MB ; Soria, AH ; Hübner, CA ; Fernandes-Rosa, FL & al
Nat Commun, 2019 Oct 15, PMID: 31615979 PMCID: PMC6794291 DOI: 10.1038/s41467-019-12113-9

  • Functional investigations and acquired tubular nephropathies: let’s make it simple/ Nancy/ P. Houillier/ Nephrologists
  • Disorders of calcium and magnesium/Budapest P. Houillier/ Nephrologists
  • Dent syndrome/Venise-International Pediatric Nephrology Association (IPNA)/R. Vargas-Poussou/Pediatric nephrologists
  • Pseudohypoaldosteronism/Venise-IPNA/R. Vargas-Poussou/Pediatric nephrologists
  • X-linked transient antenatal Bartter syndrome/ Tours/ R Vargas-Poussou/ Geneticists
  • Infantile hypercalcemia with nephrocalcinosis and uniparental disomy of chromosome 20/ Tours/ M. Hureaux/Geneticists
  • Applying multi-omics in adrenal hypertension/ENDO2019, New Orleans/MC Zennaro/Endocrinologists
  • Endocrine Hypertension/British and Irish Hypertension Society, Birmingham, UK/MC Zennaro/Cardiologists
  • Genetics in Primary Aldosteronism/ Seou/ MC Zennaro/Endocrinologists
  • Vascular and hormonal interactions in primary aldosteronism. 2020 European ECCR Virtual meeting/ MC Zennaro/ Cardiologists
  • Applying Omics-Based Approaches for the Diagnosis of Endocrine Hypertension. A, Lucca, Italy/ MC Zennaro/ Cardiologists, endocrinologists and researchers
  • MultiOMICS and endocrine hypertension/ Munich, Germany/ MC Zennaro/ Cardiologists, endocrinologists and researchers

Contact information

Georges-Pompidou european hospital
> Genetics department

20 rue Leblanc
75015 Paris

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At the Georges-Pompidou european hospital, the reference center for hereditary kidney diseases in children and adults (MARHEA) in brief …

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patients followed at least once a year*
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medical consultations*
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day hospitalizations*
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fully hospitalized patients*
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teleconsultation procedures*
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patient trained in therapeutic education*
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ongoing research projects*
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university courses*
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publications*

* data valid for 2022